It's not just the world of mutants that's changing after "House Of M." The comics are also going through yet another revamp and creative shift, before the next movie comes out and before the 500th issue of Uncanny X-Men. Ed Brubaker is favourite to write "Uncanny X-Men," while Chris Claremont is being shunted off the central titles yet again...
So long as he keeps Rachel, he may proceed. I like his X-Men take in Deadly Genesis, so no problems there.